Coenzyme Q10 with clinically proven superior absorption
QUVITAL line presents high quality food supplements based on water-soluble form of Coenzyme Q10 (Q10Vital) with clinically proven 4-times higher bioavailability, excellent absorption and proven efficiency.
Superior biavailability means that with taking 1 capsule or 1 tea-spoon of Quvital CoQ10 syrup your body »uses« more Coenzyme Q10 than with other products (soft gel capsules). Or, in other words: to achieve the same result as with 1 unit of water soluble coenzyme Q10 in Quvital products, you have to take 2, 3 or in some cases even 4 capsules from other manufacturers.
Besides superior biavailability, Quvital line offers the most diverse range of CoQ10 food supplements, suitable for different needs and tastes. With liquid formulations like syrups and oral sprays you can now optimize your daily intake of CoQ10 by distributing it several times through the day. This kind of intake was proven to be much more effective in compare to strong dosing of CoQ10 with one capsule.
Quvital Q10 presents food supplements that contain a unique water – soluble form of Coenzyme Q10 with a highly improved efficiency and bioavailability, meaning that less of it has to be consumed for the same or a stronger effect in comparison to regular formulations. The enhanced water solubility has also enabled us to prepare water-based products such as syrups,representing a novelty on the market.
Graph: Bioavailability and efficiency of water soluble form of coenzyme Q10, used in Quvital Q10 products, is significantly higher than with other competitive products with Q10 in the market.
Patented water – soluble form ob Q10 with clinically proven superior bioavailability
Coenzyme Q10 is a naturally occurring fat-soluble compound present in each and every living cell and is essential for the functioning of an organism. Most of Q10 products in the market are made based on crystalline Q10 or oily ingredients (soft-gel formulations) which are very difficult for human body to “use”. Most of such fat-soluble forms “flush out” among digesting, before Q10 reaches bloodstream and has significant effect in the body. Scientists have solved this problem by developing unique water – soluble form of Q10, which enables up to 4 times better absorption and thus greater efficiency of Q10 in organism.
Scientists have developed a unique water-soluble form of Q10 with superior bioavailability that makes Quvital Q10 products very effective and simple to use.
Quvital Q10 syrups and capsules are suitable for men and women after 25 years and are especially recommended to:
- all people, who appreciate healthy lifestyle and vitality
- all who realize the meaning of prevention in anti-ageing process
- all who are taking drugs to lower cholesterol level (statines)
- people under daily stress in work or personal life
- active sportsmen and people involved in heavy physical activities
- Γpatients and all who are recovering after illness
- people with risk factors at any age
Advantages of Quvital Q10
- Patent: unique patented formula of water-soluble Q10
- Clinically proven efficiency: superior, up to 4 times stronger bioavailability
- Exclusive: the only syrup with Q10 in the European market
- Easy to use: you can take Quvital alone or mix it with water, tea or juice
- Wide range: available in capsules and syrups in various concentrations to cover everyone’s needs
- Suitable for vegetarians: both sryups and capsules
Quvital Q10 is the most complete line of products with Coenzyme Q10 in the European market.
Q10 capsules 50 mg
Each capsule contains 50 mg of water-soluble form of Q10 and covers the need for people over the age of 40 and people with the need for greater dosage of Q10. Capsules are made on cellulose base and therefore (unlike most gelatine capsules) suitable also for vegetarians. Capsules also contains thiamine (B1) and riboflavin (B2) for optimal energy release and heart health support.
Packaging: 30 capsules
About Coenzyme Q10 !
Coenzyme Q10 is an essential component of cellular energy formation and a very effective antioxidant.
Coenzyme Q10 is a naturally occurring fat-soluble compound present in each and every living cell; due to its ubiquitous occurrence in nature it is also called Ubiquinone. It is essential for the functioning of an organism.
The predominant form in humans and most animals is Coenzyme Q10, containing 10 isoprenoid units attached to the quinone moiety. It is now well established that Q10 is an essential component of the mitochondrial energy metabolism (Nobel Prize). Coenzyme Q10 is responsible for energy conversion from carbohydrates and fatty acids into high-energy adenosine triphosphate (ATP), which plays an integral role in supplying energy to chemical reactions in the body and therefore driving cellular machinery and synthesis.
Q10 as an antioxidant
Q10 has been known to be a very effective antioxidant for over 40 years, protecting against lipid peroxidation, DNA and protein oxidation and being capable of functioning synergistically with other antioxidants.
A key advantage of Q10 lies in its presence in the mitochondria, the main source of free radicals. For this reason, it can be more effective than other antioxidants which are more evenly distributed throughout a cell.
Due to its many positive effects, also in anti ageing process , Q10 is also known as ELIXIR OF YOUTH and it’s often
used in cosmetic industry. However, due to protective property of human skin, Q10 used in creams can hardly penetrate deeper. By using Q10 in Quvital products, Q10 reaches our blood system directly and thus
supplies the skin cells.
UBIQUINONE ΚΑΙ UBIQUINOL
Q10 is present in the human body in both an oxidized and a reduced form. Ubiquinone is reduced to ubiquinol during or following absorption in the intestine, consequently its function is not affected by the form in which it is consumed.
Sources and deficiency
The human body biosynthesizes Q10, but its endogenous tissue levels decrease progressively after the age of 21. A deficiency has also been observed in various medical conditions, in people with inappropriate nutrition and in smokers. Besides biosynthesis, small amounts of Q10 are supplied to the organism by various foods (3-5 mg/day), mostly from meat and fish. Such an intake is clearly not enough to compensate for age-connected decline. Therefore, daily supplementation of Q10 is recommended.
If an adult person wanted to compensate the lack of coenzyme Q10 which decreases due to aging and other risk factors (smoking, stress, statins, etc), one would have to ingest at least half a kilo of sardines, 1 kilo of fat meat or 15 litres of fresh wholefat milk, which is in absolute contradiction to nutritional requirements and dietary recomendations.
Now imagine being a vegetarian…
> Diagram: Concentration of coenzyme Q10 in most active human organs decreases with age.
Οφέλη για την υγεία
Coenzyme Q10 can slow down the ageing process, what was also confirmed in skin, where reduction of wrinkles was observed. Beneficial contribution of supplemental Q10 has been found in various conditions, such as cardiovascular diseases, various mitochondrial diseases, neurodegenerative diseases, migraine, cancer, support of the immune system, periodontal disease, male infertility and in persons with decreased levels of Q10 (i.e. due the use of cholesterol-lowering drugs -statins).
Q10 was first approved as a drug in Japan and later also in some other countries, while in most countries it has been widely used as a food supplement. The safety of oral Q10 administration for humans has been shown in many clinical trails. Very high and chronic exposures have also been studied. No abnormal changes in clinical parameters or serious adverse events were observed in a study in which healthy human adults received high chronic dosages of Q10. The data from preclinical and clinical studies show that Q10 is very safe for use as a dietary supplement.
Why is Quvital more effective
A patented* water-soluble form of Coenzyme Q10 (Q10) with a highly improved efficiency and bioavailability is used in QUVITAL Q10 products, meaning that less of it has to be consumed for the same or a stronger effect in comparison to regular formulations. In this innovative product every single molecule of lipophilic Q10 is entrapped in the lipophilic cavity of a β-cyclodextrin (β-CD) molecule, a starch derivative with a hydrophilic outer surface, making it apparently hydrophilic and soluble in aqueous media (see Figure).
< Figure: A model of a novel form of Q10, which is used in ORTO™ products – solubility of Q10 in diverse aqueous media was achieved with its inclusion into the lipophilic cavity of a starch derivative β-cyclodextrin.
Bioavailability of Q10 in Quvital products
The efficiency of orally-ingested products depends on their absorption in the gastrointestinal tract. The superior bioavailability of the unique water-soluble form of Coenzyme Q10 (Q10Vital) used in QUVITAL Q10 products has been determined by independent bioequivalence studies, showing about 400% bioavailability when compared to crystalline Q10.
A pharmacokinetic study on healthy human volunteers showed a statistically significant 120% increase over the reference soft-gel capsules for Q10Vital. Even better results were observed in a study in which Q10Vital was administered with food – a 260% increase in bioavailability over the reference soft-gel capsules was determined, representing 422% of the bioavailability of crystalline Q10 (Figure).
Improving the bioavailability of CoQ10: From theory to practice
Žmitek, J, Žmitek, K & Pravst, I. (2008) Agro Food Ind. Hi Tec. 19, 4: 9-10.
Relative bioavailability of two forms of a novel water soluble CoQ10
Žmitek, J, Šmidovnik, A, Fir, M, Prošek, M, Žmitek, K, Walczak, J & Pravst, I. (2008), Ann. Nutri. Metab. 52:281-287.
Bioavailability of water soluble CoQ10 in beagle dogs
Prošek, M, Butinar, J, Lukanc, B, Fir Milivojevič, M, Milivojevič, L, Križman, M & Šmidovnik, A. (2008) J. Pharm. Biomed. Anal. 47:918-922.
Health benefits of Q10
The accumulation of damage to the organism caused by free radicals represents an important part of the ageing process. As Q10 is present exactly where the majority of free radicals are generated it has a fundamental influence on the ageing process. Since the levels of Q10 in various tissues reduce with increasing age, supplementation can restore normal levels and slow down the ageing process.
> Diagram: Concentration of coenzyme Q10 in most active human organs decreases with age.
Cardiovascular diseases are the leading cause of morbidity and mortality in the Western world. A decline in Q10 concentration in an ageing heart has been connected with various cardiovascular diseases. The beneficial effects of Q10 supplementation have been shown in many studies. Oral Q10 improves functional capacity, endothelial function and left ventricular systolic function in advanced chronic heart failure without any side effects. Q10 may also safely be offered as an adjuvant therapy to hypertensive and angina patients.
CHOLESTEROL AND STATINS
Statins are drugs used to lower raised blood cholesterol levels, which have been associated with increased risk of heart disease. However, these drugs also influence the biosynthesis of Q10 and its plasma levels are lowered in the course of statin treatment. Statins competitively restrict the synthesis of mevalonate, a cholesterol precursor. Unfortunately, mevalonate is also the precursor of a dozen other end-products, including Q10. Compensating for such a Q10 decrease through the oral administration of Q10 is therefore often suggested.
Patients with various neurodegenerative diseases have also been successfully treated. Substantial data have been accumulated about the beneficial effects of Q10 in neurodegenerative diseases in which there is impaired mitochondrial function and/or excessive oxidative damage, including Parkinson’s disease, Huntington’s disease and Friedreich’s ataxia. Clinical trials suggest that supplemental Q10 can slow down functional decline in these disorders.
The efficiency of Q10 as a preventive treatment for migraine headaches was first investigated in 2002. The average number of days with a migraine was halved after 3 months of therapy with Q10. It was further reported that a Q10-deficiency may be common to migraine patients, while an efficacious and well tolerated treatment was also confirmed by a randomised control trial.
The supplementation of Q10 can sometimes improve the tolerability of cancer treatments. In individual cases, a partial or complete regression of cancer has also been observed in relation to Q10 supplementation.
Beneficial effects of Q10 have also been reported in support of the immune system, the treatment of periodontal disease, male infertility and many other conditions
DOCTOR’S OPINION ON QUVITAL FORTE SYRUP
Products from the Quvital line have for years been successfully used to alleviate the symptoms of children with mitochondrial diseases at the Children’s Hospital of the University Medical Centre Ljubljana. The following is an opinion regarding our products, prepared by Prof. Dr. David Neubauer, MD, Senior Councillor, Head of the Department of Paediatric Neurology at the Children’s Hospital of the University Medical Centre Ljubljana:
In addition to the effect coenzyme Q10 has on the inhibition of the aging process, it has proved to be very effective in the clinical practice of the relief of symptoms of a number of severe diseases such as various heart diseases, hepatic impairments, neurologic disorders and, in particular, so-called degenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s disease) (1). Among these severe diseases, many forms of mitochondrial diseases are included, in particular during the period of childhood (2, 3). Recently, it has even been proven that there are genetically confirmed forms of childhood mitochondrial diseases, the main cause of which is primarily a deficiency of coenzyme Q10 (4). These diseases require treatment with doses of supplementary coenzyme Q10. So far, capsules were most commonly used for this purpose, in particular soft gelatine capsules containing coenzyme Q10, which are the most accessible form of this coenzyme due to their lipophilic properties, and they are also the most common form found on the market. The latter contain coenzyme Q10, which is partly or completely dissolved in an oil base.
Recently, water-soluble forms of this coenzyme can also be found on the market; the majority of the published data show that with the increased water-solubility, bioavailability also increases (5, 6), as well the possibility of preparation of various other pharmaceutical forms, which were until now inaccessible or less accessible. In this context, Valens Int. offered us Quvital syrup (we agreed to test it), which contains a special, water-soluble form of coenzyme Q10 that was developed and patented by the National Institute of Chemistry in Ljubljana (Patent SI 21783, WO 2005/111224 A2). The base of the syrup is natural concentrated fruit juice with no added sweeteners or preservatives. The concentration of the coenzyme Q10 in the Quvital syrup used is 15 mg/mL.
In using Quvital syrup, we wished to determine its potential advantages in comparison with the use of soft gelatine capsules from the perspective of its acceptability among our little patients and from the perspective of its clinical effects. To this end, we have substituted the soft gelatine capsules containing coenzyme Q10 in all cases of children with severe forms of confirmed or clinically very probable mitochondrial diseases with equal or lower doses of this coenzyme in the form of Quvital syrup. In particular, we have determined an exceptionally good acceptability of the syrup in most children and, subsequently, an anamnestically and objectively determined improvement of clinical effects in relation to equal or higher doses of coenzyme Q10 in the form of soft gelatine capsules.
According to our experiences, Quvital syrup is a very welcome and useful innovation for anyone who favours liquid forms of medicines or has difficulties in consuming capsules or receives a large number of solid forms of medicines for oral use; this innovation is particularly welcome among children and the elderly. It enables adjustment of dosage to an individual’s needs, both in terms of quantity and administration. The syrup can be taken undiluted or as a cold or warm drink when diluted in water, tea, etc. It is therefore understandable that all of the children (as well as their parents) have accepted the syrup as a great innovation.
In addition to good acceptability among patients, the clinical efficiency of the syrup was also obvious, as the anamnestical and clinical condition of children improved significantly after the substitution of capsules with the syrup in equal and even in lower doses.
In the light of our experience, I estimate that similar effects can be expected in other conditions and diseases related to a deficiency of coenzyme Q10.
J. Challem, Feed Your Genes Right: Eat to Turn off Disease-causing Genes and Slow Down Aging,
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Lopez LC, Schuelke M, Quinzii CM et al. Leigh syndrome with nephropathy and CoQ10 deficiency due to
decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am J Hum Genet 2006;79:1125-1129.
Miles MV et al. Nutrition Res 2002; 22:919-929.
Chopra K et al. Internat J Vit Nutr Res 1998;68:109-113.
Scientific literature about Coenzyme Q10:
The vital biological functions of Coenzyme Q10, its beneficial contribution to human health and its safety have all been confirmed in numerous scientific investigations. Some of interesting scientific sources include:
Žmitek et al. Koencim Q10 kot prehransko dopolnilo in zdravilo, Farmacevtski vestnik 2009, 3, 150.
Pavlin. Koencim Q10 – Klinična raba, Zdrav. vest. 2008, 77, 97.
Bhagavan et al. Mitochondrion 2007, 7, S78.
Coenzyme Q: Biochemistry, Bioenergetics, and Clinical Applications of Ubiquinone; John Wiley & Sons: Chichester, 1985.
Crane J. Am. Coll. Nutr. 2001, 20, 591.
Mellors et al. J. Biol. Chem. 1966, 241, 4353.
Frei et al. Proc. Natl. Acad. Sci. U. S. A. 1990, 87, 4879.
Challem. Nutrients That Enhance Energy and Prevent DNA Damage.
In Feed Your Genes Right; John Wiles & Sons: Hoboken, New Jersey, 2005.
Sastry et al. Nature 1961, 189, 577.
Kalén et al. Lipids 1989, 24, 579.
Quinzii et al. Neurochem. Res. 2007, 32, 723.
Elsayed et al. Nutr Res 2001, 21, 551.
Weber et al. Mol. Aspects Med. 1997, 18, S251.
Ely et al. J Orthomol Med 2000, 15, 63.
Bribiva et al. Nonenzymatic Antioxidant Defense Systems. In Natural Antioxidants
in Human Health and Disease; Frei., Ed.; AP Inc.: San Diego, 1994.
Linnane et al. Ann. NY. Acad. Sci. 2002, 959, 396.
Vormann. Agro Food Ind Hi Tec 2004, 15, 34.
Singh et al. Nutr. Rev. 2007, 65, 286.
Belardinelli et al. Eur. Heart J. 2006, 27, 2675.
Burke et al. South Med J 2001, 94, 1112.
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Littarru et al. Mitochondrion 2007, 7, S168.
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Rozen et al. Cephalalgia 2002, 22, 137.
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Kikkawa et al. Jpn. J. Food Chem. 2007, 14, 76.
Hidaka et al. The 5th conf. of the Int. CoQ10 Assoc.: Overview of safety assessment of CoQ10: Animal and human data. 2007.dr